FASN, dietary fat intake, and risk of uterine leiomyomata in the Black Women's Health Study.

ABSTRACT:

Objective

To replicate results from a previous genome-wide association study of European ancestry women, in which a positive association was found between uterine leiomyomata (UL) and rs4247357, a single-nucleotide polymorphism located near the fatty acid synthase (FASN) gene.

Design

Prospective cohort study.

Setting

Not applicable.

Patient(s)

African-American women aged 23-50 years, who were premenopausal and had an intact uterus in 1997.

Intervention(s)

None.

Main outcome measure(s)

We genotyped rs4247357 among 2,301 incident UL cases and 3,005 controls from the Black Women's Health Study (1997-2011). Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using logistic regression with control for age, geographic region of residence,

SUBMITTER: Wise LA 

PROVIDER: S-EPMC5048502 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature