Androgen responses to adrenocorticotropic hormone infusion among individual women with polycystic ovary syndrome.

ABSTRACT:

Objective

To compare androgen responses during ACTH infusion among women with polycystic ovary syndrome (PCOS) and healthy women.

Design

Cross-sectional study.

Setting

Academic medical center.

Patient(s)

Women with PCOS (n = 13) and healthy controls (n = 15).

Intervention(s)

Blood samples were obtained frequently during a 6-hour dose-response ACTH infusion.

Main outcome measure(s)

Comparison of basal and stimulated levels of 17α-hydroxyprogesterone (17-OHP), androgens, and cortisol (F) during ACTH infusion with those after hCG injection within individual subjects.

Result(s)

In women with PCOS increased 17-OHP, androstenedione (A), and DHEA responses during ACTH infusion were comparable to those observed in healthy controls. The magnitude of

SUBMITTER: Maas KH 

PROVIDER: S-EPMC5048513 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature