Mapping the neuropsychological profile of temporal lobe epilepsy using cognitive network topology and graph theory.

ABSTRACT:

Objective

Normal cognitive function is defined by harmonious interaction among multiple neuropsychological domains. Epilepsy has a disruptive effect on cognition, but how diverse cognitive abilities differentially interact with one another compared with healthy controls (HC) is unclear. This study used graph theory to analyze the community structure of cognitive networks in adults with temporal lobe epilepsy (TLE) compared with that in HC.

Methods

Neuropsychological assessment was performed in 100 patients with TLE and 82 HC. For each group, an adjacency matrix was constructed representing pair-wise correlation coefficients between raw scores obtained in each possible test combination. For each cognitive network, each node corresponded to a cognitive test; each link correspo

SUBMITTER: Kellermann TS 

PROVIDER: S-EPMC5048539 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature