Acute cortisol reactivity attenuates engagement of fronto-parietal and striatal regions during emotion processing in negative mood disorders.

ABSTRACT:

Objective

Depression and bipolar disorder (negative mood disorders, NMD) are associated with dysregulated hypothalamic-pituitary-adrenal (HPA)-axis function and disrupted emotion processing. The neural networks involved in attenuation of HPA-axis reactivity overlap with the circuitry involved in perception and modulation of emotion; however, direct links between these systems are understudied. This study investigated whether cortisol activity prior to undergoing fMRI was related to neural processing of emotional information in participants with NMD.

Methods

Forty-one adults (M_age=40.33, SD=15.57) with major depression (n=29) or bipolar disorder (n=12) and 23 healthy control comparisons (M_age=36.43, SD=17.33) provided salivary cortisol samples prior to c

SUBMITTER: Peters AT 

PROVIDER: S-EPMC5048542 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature