Ontology highlight
ABSTRACT:
SUBMITTER: Yang JA
PROVIDER: S-EPMC5048571 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Molecular and cellular endocrinology 20160806
Arcuate neurons that coexpress kisspeptin (Kiss1), neurokinin B (Tac2), and dynorphin (Pdyn) mediate negative feedback of 17β-estradiol (E2) on the HPG axis. Previous studies report that fasting and caloric restriction reduce arcuate Kiss1 expression. The objective of this study was to determine the interactions of E2 with fasting, caloric restriction, and diet-induced obesity on KNDy gene and receptor expression. Ovariectomized female mice were separated into control and estradiol benzoate (E2B ...[more]