Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates.

ABSTRACT: Epigenome-wide DNA methylation association studies have identified highly replicable genomic loci sensitive to maternal smoking during gestation. The role of inter-individual genetic variation in influencing DNA methylation, leading to the possibility of confounding or bias of such associations, has not been assessed. We investigated whether the DNA methylation levels at the top 10 CpG sites previously associated with exposure to maternal smoking during gestation were associated with individual genetic variation at the genome-wide level. Genome-wide association tests between DNA methylation at the top 10 candidate CpG and genome-wide SNPs were performed in 736 case and control participants of the California Childhood Leukemia Study. Three of the strongest maternal-smoking sensitive CpG sit

SUBMITTER: Gonseth S 

PROVIDER: S-EPMC5048731 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature