Calibrated Bioresorbable Microspheres as an Embolic Agent: An Experimental Study in a Rabbit Renal Model.

ABSTRACT:

Purpose

To evaluate the time frame of resorption and tissue response of newly developed bioresorbable microspheres (BRMS) and vessel recanalization after renal embolization.

Materials and methods

Embolization of lower poles of kidneys of 20 adult rabbits was performed with BRMS (300-500 µm). Two rabbits were sacrificed immediately after embolization (day 0). Three rabbits were sacrificed after follow-up angiography at 3, 7, 10, 14, 21, and 30 days. The pathologic changes in the renal parenchyma, BRMS degradation, and vessel recanalization were evaluated histologically and angiographically.

Results

Embolization procedures were successfully performed, and all animals survived without complication. Infarcts were observed in all kidneys that received embolization harveste

SUBMITTER: Weng L 

PROVIDER: S-EPMC5048746 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature