Isolation and characterization of new secondary metabolites from Asphodelus microcarpus.

ABSTRACT: Phytochemical study of the ethanolic extract of Asphodelus microcarpus Salzm. et Viv. (Asphodelaceae) resulted in the isolation of two new compounds, methyl-1,4,5-trihydroxy-7-methyl-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate (1), and (1R) 3,10-dimethoxy-5-methyl-1H-1,4-epoxybenzo[h]isochromene (2) as well as three known compounds; 3,4-dihydroxy-methyl benzoate (3), 3,4-dihydroxybenzoic acid (4), and 6-methoxychrysophanol (5). Compound 1 showed a potent activity against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus with IC₅₀ values of 1.5 and 1.2 µg/mL, respectively. Compound 3 showed antileishmanial activity with an IC₅₀ value of 33.2 µg/mL.

SUBMITTER: Ghoneim MM 

PROVIDER: S-EPMC5048751 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature