Parental risk factors for oral clefts among Central Africans, Southeast Asians, and Central Americans.

ABSTRACT:

Background

Several lifestyle and environmental exposures have been suspected as risk factors for oral clefts, although few have been convincingly demonstrated. Studies across global diverse populations could offer additional insight given varying types and levels of exposures.

Methods

We performed an international case-control study in the Democratic Republic of the Congo (133 cases, 301 controls), Vietnam (75 cases, 158 controls), the Philippines (102 cases, 152 controls), and Honduras (120 cases, 143 controls). Mothers were recruited from hospitals and their exposures were collected from interviewer-administered questionnaires. We used logistic regression modeling to estimate odds ratios (OR) and 95% confidence intervals (CI).

Results

Family history of clefts was st

SUBMITTER: Figueiredo JC 

PROVIDER: S-EPMC5049483 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature