Motivational Context Modulates Prediction Error Response in Schizophrenia.

ABSTRACT:

Background

Recent findings demonstrate that patients with schizophrenia are worse at learning to predict rewards than losses, suggesting that motivational context modulates learning in this disease. However, these findings derive from studies in patients treated with antipsychotic medications, D2 receptor antagonists that may interfere with the neural systems that underlie motivation and learning. Thus, it remains unknown how motivational context affects learning in schizophrenia, separate from the effects of medication.

Methods

To examine the impact of motivational context on learning in schizophrenia, we tested 16 unmedicated patients with schizophrenia and 23 matched controls on a probabilistic learning task while they underwent functional magnetic resonance imaging (fMRI

SUBMITTER: Reinen JM 

PROVIDER: S-EPMC5049527 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature