Variation in allergen content in sublingual allergen immunotherapy with house dust mites.

ABSTRACT:

Background

Allergen immunotherapy is a treatment modality which can be applied using different vaccines. The aim of this study was to quantify and compare the allergen content of different house dust mites (HDM)' sublingual treatments and to review the evidence on their efficacy.

Methods

Five sublingual allergen immunotherapy (SLIT) products were ordered and purchased at an ordinary pharmacy and masked for blinding before the study was started. Detection of Dermatophagoides pteronyssinus and Dermatophagoides farinae allergens Der p 1, Der f 1, Der p 2 and Der f 2 was carried out by immunoblotting and fluorescent multiplex. A literature search for meta-analyses and systematic reviews that included SLIT-HDM products was performed.

Results

Der p 1 concentrations ranged f

SUBMITTER: Moreno Benitez F 

PROVIDER: S-EPMC5049613 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature