MicroRNA changes in liver tissue associated with fibrosis progression in patients with hepatitis C.

ABSTRACT:

Background & aims

Accumulating evidence indicates that microRNAs play a role in a number of disease processes including the pathogenesis of liver fibrosis in hepatitis C infection. Our goal is to add to the accruing information regarding microRNA deregulation in liver fibrosis to increase our understanding of the underlying mechanisms of pathology and progression.

Methods

We used next generation sequencing to profile all detectable microRNAs in liver tissue and serum from patients with hepatitis C, stages F1-F4 of fibrosis.

Results

We found altered expression of several microRNAs, in particular, miR-182, miR199a-5p, miR-200a-5p and miR-183 were found to be significantly upregulated in tissue from liver biopsies of hepatitis C patients with advanced fibrosis, stage F3

SUBMITTER: Van Keuren-Jensen KR 

PROVIDER: S-EPMC5049661 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature