Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men: Results from the Danish Blood Donor Study (DBDS).

ABSTRACT:

Introduction

The aim of this study was to examine whether low-grade inflammation (LGI) is associated with a subsequently increased risk of infection.

Methods

We included 15,754 healthy participants from the Danish Blood Donor Study, who completed a questionnaire on health-related items. LGI was defined as a C-reactive protein level between 3 and 10 mg/L. Infections were identified by ICD-10 codes in the Danish National Patient Register and ATC-codes in the Danish Prescription Register. Multivariable Cox proportional hazard analysis was used as the statistical model.

Results

During 53,302 person-years of observation, 571 participants were hospitalized for infection. Similarly, during 26,125 person-years of observation, 7,276 participants filled a prescription of antimi

SUBMITTER: Kaspersen KA 

PROVIDER: S-EPMC5049789 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature