Chemotherapy and Stem Cell Transplantation Increase p16^INK4a Expression, a Biomarker of T-cell Aging.

ABSTRACT: The expression of markers of cellular senescence increases exponentially in multiple tissues with aging. Age-related physiological changes may contribute to adverse outcomes in cancer survivors. To investigate the impact of high dose chemotherapy and stem cell transplantation on senescence markers in vivo, we collected blood and clinical data from a cohort of 63 patients undergoing hematopoietic cell transplantation. The expression of p16^INK4a, a well-established senescence marker, was determined in T-cells before and 6months after transplant. RNA sequencing was performed on paired samples from 8 patients pre- and post-cancer therapy. In patients undergoing allogeneic transplant, higher pre-transplant p16^INK4a expression was associated with a greater number of prior c

SUBMITTER: Wood WA 

PROVIDER: S-EPMC5049997 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature