BRG1 in the Nucleus Accumbens Regulates Cocaine-Seeking Behavior.

ABSTRACT:

Background

Drug addiction is defined as a chronic disease characterized by compulsive drug seeking and episodes of relapse despite prolonged periods of drug abstinence. Neurobiological adaptations, including transcriptional and epigenetic alterations in the nucleus accumbens, are thought to contribute to this life-long disease state. We previously demonstrated that the transcription factor SMAD3 is increased after 7 days of withdrawal from cocaine self-administration. However, it is still unknown which additional factors participate in the process of chromatin remodeling and facilitate the binding of SMAD3 to promoter regions of target genes. Here, we examined the possible interaction of BRG1-also known as SMARCA4, an adenosine triphosphatase-containing chromatin remodeler-and SMAD

SUBMITTER: Wang ZJ 

PROVIDER: S-EPMC5050080 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature