Metformin, Diabetes, and Survival among U.S. Veterans with Colorectal Cancer.

ABSTRACT:

Background

Metformin has been associated with improved colorectal cancer survival, but investigations are limited by small numbers of patients and confounding by diabetic severity. We examined the association between metformin use and overall survival (OS) in patients with diabetes and colorectal cancer in a large population of U.S. veterans, while adjusting for measures of diabetic severity.

Methods

Patients diagnosed with colorectal cancer from January 2001 to December 2008 were identified from the Veterans Affairs Central Cancer Registry. Multivariable models were used to examine the adjusted association of OS with diabetes and use of antidiabetic medications.

Results

There were 21,352 patients diagnosed with colorectal cancer identified (n = 16,355 nondiabetic pat

SUBMITTER: Paulus JK 

PROVIDER: S-EPMC5050110 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature