Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes.

ABSTRACT:

Aims

To assess associations between body mass index (BMI), waist circumference (WC), and computed tomography-determined volumes of pericardial, visceral, and subcutaneous adipose tissue with magnetic resonance imaging-(MRI) based cerebral structure and cognitive performance in individuals with type 2 diabetes (T2D).

Methods

This study was performed in 348 African Americans (AAs) and 256 European Americans (EAs) with T2D. Associations between adiposity measures with cerebral volumes of white matter (WMV), gray matter (GMV), white matter lesions, hippocampal GMV, and hippocampal WMV, cognitive performance and depression were examined using marginal models incorporating generalized estimating equations. All models were adjusted for age, sex, education, smoking, HbA1c, hypertens

SUBMITTER: Hsu FC 

PROVIDER: S-EPMC5050135 | biostudies-literature | 2016 Nov - Dec

REPOSITORIES: biostudies-literature