Vascular Targeted Radioimmunotherapy for the Treatment of Glioblastoma.

ABSTRACT: Glioblastoma is characterized by an aggressive and aberrant vascular network that promotes tumor progression and hinders effective treatment; the median survival is 16 mo despite standard-of-care therapies. There is a need to improve therapeutic options for this disease. We hypothesized that antibody targeting of the vascular endothelium of glioblastoma with cytotoxic short-range, high-energy α-particles would be an effective therapeutic approach.

Methods

E4G10, an antibody directed at an epitope of monomeric vascular endothelium cadherin that is expressed in tumor neovasculature and on endothelial progenitor cells in the bone marrow, was labeled with α-particle-emitting ²²⁵Ac. Pharmacokinetic studies investigated the tissue distribution and blood clearance of the ²²

SUBMITTER: Behling K 

PROVIDER: S-EPMC5050148 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature