A cytosolic carbonic anhydrase molecular switch occurs in the gills of metamorphic sea lamprey.

ABSTRACT: Carbonic anhydrase plays a key role in CO₂ transport, acid-base and ion regulation and metabolic processes in vertebrates. While several carbonic anhydrase isoforms have been identified in numerous vertebrate species, basal lineages such as the cyclostomes have remained largely unexamined. Here we investigate the repertoire of cytoplasmic carbonic anhydrases in the sea lamprey (Petromyzon marinus), that has a complex life history marked by a dramatic metamorphosis from a benthic filter-feeding ammocoete larvae into a parasitic juvenile which migrates from freshwater to seawater. We have identified a novel carbonic anhydrase gene (ca19) beyond the single carbonic anhydrase gene (ca18) that was known previously. Phylogenetic analysis and synteny studies suggest that both carbonic

SUBMITTER: Ferreira-Martins D 

PROVIDER: S-EPMC5050428 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature