The Principles of Ligand Specificity on beta-2-adrenergic receptor.

ABSTRACT: G protein-coupled receptors are recognized as one of the largest families of membrane proteins. Despite sharing a characteristic seven-transmembrane topology, G protein-coupled receptors regulate a wide range of cellular signaling pathways in response to various physical and chemical stimuli, and prevail as an important target for drug discovery. Notably, the recent progress in crystallographic methods led to a breakthrough in elucidating the structures of membrane proteins. The structures of β₂-adrenergic receptor bound with a variety of ligands provide atomic details of the binding modes of agonists, antagonists and inverse agonists. In this study, we selected four representative molecules from each functional class of ligands and investigated their impacts on β₂-ad

SUBMITTER: Chan HC 

PROVIDER: S-EPMC5050457 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature