Optogenetic activation of septal GABAergic afferents entrains neuronal firing in the medial habenula.

ABSTRACT: The medial habenula (MHb) plays an important role in nicotine-related behaviors such as nicotine aversion and withdrawal. The MHb receives GABAergic input from the medial septum/diagonal band of Broca (MS/DB), yet the synaptic mechanism that regulates MHb activity is unclear. GABA (γ -aminobutyric acid) is a major inhibitory neurotransmitter activating both GABA_A receptors and GABA_B receptors. Depending on intracellular chloride concentration, however, GABA_A receptors also function in an excitatory manner. In the absence of various synaptic inputs, we found that MHb neurons displayed spontaneous tonic firing at a rate of about ~4.4 Hz. Optogenetic stimulation of MS/DB inputs to the MHb evoked GABA_A receptor-mediated synaptic currents, which produ

SUBMITTER: Choi K 

PROVIDER: S-EPMC5050514 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature