New low-flux mixed matrix membranes that offer superior removal of protein-bound toxins from human plasma.

ABSTRACT: Hemodialysis is a widely available and well-established treatment for patients with End Stage Renal Disease (ESRD). However, although life-sustaining, patient mortality rates are very high. Several recent studies corroborated the link between dialysis patients' outcomes and elevated levels of protein-bound uremic toxins (PBUT) that are poorly removed by conventional hemodialysis. Therefore, new treatments are needed to improve their removal. Recently, our group showed that the combination of dialysis and adsorption on one membrane, the mixed matrix membrane (MMM), can effectively remove those toxins from human plasma. However, these first MMMs were rather large in diameter and their mass transport characteristics needed improvement before application in the clinical setting. Therefore, in

SUBMITTER: Pavlenko D 

PROVIDER: S-EPMC5050520 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature