Matrix factorization reveals aging-specific co-expression gene modules in the fat and muscle tissues in nonhuman primates.

ABSTRACT: Accurate identification of coherent transcriptional modules (subnetworks) in adipose and muscle tissues is important for revealing the related mechanisms and co-regulated pathways involved in the development of aging-related diseases. Here, we proposed a systematically computational approach, called ICEGM, to Identify the Co-Expression Gene Modules through a novel mathematical framework of Higher-Order Generalized Singular Value Decomposition (HO-GSVD). ICEGM was applied on the adipose, and heart and skeletal muscle tissues in old and young female African green vervet monkeys. The genes associated with the development of inflammation, cardiovascular and skeletal disorder diseases, and cancer were revealed by the ICEGM. Meanwhile, genes in the ICEGM modules were also enriched in the adipocy

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5050522 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature