Performance and time to become negative after treatment of three malaria rapid diagnostic tests in low and high malaria transmission settings.

ABSTRACT:

Background

The performance of different malaria rapid diagnostic tests (RDT) may be influenced by transmission intensity and by the length of time each test requires to become negative after treatment and patient's recovery.

Methods

Results of three RDTs (two HRP2 and one pLDH antigen-based tests) were compared to blood smear microscopy (the gold standard method) in children under 5 years of age living in a high versus low malaria intensity setting in southwestern Uganda. In each setting, 212 children, who tested positive by at least one RDT and by microscopy, were treated with artemether-lumefantrine. RDTs and microscopy were then repeated at fixed intervals to estimate each test's time to negativity after treatment and patient recovery.

Results

In the two settings,

SUBMITTER: Grandesso F 

PROVIDER: S-EPMC5050565 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature