Association of CD247 (CD3ζ) gene polymorphisms with T1D and AITD in the population of northern Sweden.

ABSTRACT:

Background

T1D and AITD are autoimmune disorders commonly occurring in the same family and even in the same individual. The genetic contribution to these disorders is complex making uncovering of susceptibility genes very challenging. The general aim of this study was to identify loci and genes contributing to T1D/AITD susceptibility. Our strategy was to perform linkage and association studies in the relatively genetically homogenous population of northern Sweden. We performed a GWLS to find genomic regions linked to T1D/AITD in families from northern Sweden and we performed an association study in the families to test for association between T1D/AITD and variants in previously published candidate genes as well as a novel candidate gene, CD247.

Methods

DNA prepared from 459

SUBMITTER: Holmberg D 

PROVIDER: S-EPMC5050583 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature