High levels of biomarkers of collagen remodeling are associated with increased mortality in COPD - results from the ECLIPSE study.

ABSTRACT:

Background

There is a need to identify individuals with COPD at risk for disease progression and mortality. Lung tissue remodeling is associated with the release of extracellular matrix (ECM) fragments into the peripheral circulation. We hypothesized that ECM remodeling was associated with mortality in COPD and measured neo-epitopes originating from ECM proteins associated with lung tissue remodeling.

Methods

Biomarkers of ECM remodeling were assessed in a subpopulation (n = 1000) of the Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) cohort. Validated immunoassays measuring serological neo-epitopes produced by proteolytic cleavage associated with degradation of collagen type I, III, IV, and VI, elastin, and biglycan, and formation of

SUBMITTER: Sand JM 

PROVIDER: S-EPMC5050854 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature