Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics.

ABSTRACT: Metformin is a commonly prescribed diabetes medication whose mechanism of action is poorly understood. In this study we utilized EHR-linked biobank data to elucidate the impact of genomic variation on glycemic response to metformin. Our study found significant gene- and SNP-level associations within the beta-2 subunit of the heterotrimeric adenosine monophosphate-activated protein kinase complex. Using EHR phenotypes where were able to add additional clarity to ongoing metformin pharmacogenomic dialogue.

SUBMITTER: Breitenstein MK 

PROVIDER: S-EPMC5051541 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature