Development of a RNA-Seq Based Prognostic Signature in Lung Adenocarcinoma.

ABSTRACT:

Background

Precision therapy for lung cancer will require comprehensive genomic testing to identify actionable targets as well as ascertain disease prognosis. RNA-seq is a robust platform that meets these requirements, but microarray-derived prognostic signatures are not optimal for RNA-seq data. Thus, we undertook the first prognostic analysis of lung adenocarcinoma RNA-seq data and generated a prognostic signature.

Methods

Lung adenocarcinoma RNA-seq and clinical data from The Cancer Genome Atlas (TCGA) were divided chronologically into training (n = 255) and validation (n = 157) cohorts. In the training cohort, prognostic association was assessed by univariate Cox analysis. A prognostic signature was built with stepwise multivariable Cox analysis. Outcomes by risk group,

SUBMITTER: Shukla S 

PROVIDER: S-EPMC5051943 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature