Validation of a Rapid Rabies Diagnostic Tool for Field Surveillance in Developing Countries.

ABSTRACT:

Background

One root cause of the neglect of rabies is the lack of adequate diagnostic tests in the context of low income countries. A rapid, performance friendly and low cost method to detect rabies virus (RABV) in brain samples will contribute positively to surveillance and consequently to accurate data reporting, which is presently missing in the majority of rabies endemic countries.

Methodology/principal findings

We evaluated a rapid immunodiagnostic test (RIDT) in comparison with the standard fluorescent antibody test (FAT) and confirmed the detection of the viral RNA by real time reverse transcription polymerase chain reaction (RT-qPCR). Our analysis is a multicentre approach to validate the performance of the RIDT in both a field laboratory (N'Djamena, Chad) and an int

SUBMITTER: Lechenne M 

PROVIDER: S-EPMC5051951 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature