The nonessentiality of essential genes in yeast provides therapeutic insights into a human disease.

ABSTRACT: Essential genes refer to those whose null mutation leads to lethality or sterility. Theoretical reasoning and empirical data both suggest that the fatal effect of inactivating an essential gene can be attributed to either the loss of indispensable core cellular function (Type I), or the gain of fatal side effects after losing dispensable periphery function (Type II). In principle, inactivation of Type I essential genes can be rescued only by re-gain of the core functions, whereas inactivation of Type II essential genes could be rescued by a further loss of function of another gene to eliminate the otherwise fatal side effects. Because such loss-of-function rescuing mutations may occur spontaneously, Type II essential genes may become nonessential in a few individuals of a large population.

SUBMITTER: Chen P 

PROVIDER: S-EPMC5052060 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature