Measures to Predict The Individual Variability of Corticospinal Responses Following Transcranial Direct Current Stimulation.

ABSTRACT: Individual responses to transcranial direct current stimulation (tDCS) are varied and therefore potentially limit its application. There is evidence that this variability is related to the contributions of Indirect waves (I-waves) recruited in the cortex. The latency of motor-evoked potentials (MEPs) can be measured through transcranial magnetic stimulation (TMS), allowing an individual's responsiveness to tDCS to be determined. However, this single-pulse method requires several different orientations of the TMS coil, potentially affecting its reliability. Instead, we propose a paired-pulse TMS paradigm targeting I-waves as an alternative method. This method uses one orientation that reduces inter- and intra-trial variability. It was hypothesized that the paired-pulse method would correlat

SUBMITTER: Nuzum ND 

PROVIDER: S-EPMC5052268 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature