Menopause, Reproductive Life, Hormone Replacement Therapy, and Bone Phenotype at Age 60-64 Years: A British Birth Cohort.

ABSTRACT:

Context

Previous studies of menopausal age and length of reproductive life on bone are limited by retrospective reproductive histories, being cross-sectional, or lacking gold standard bone technologies or information on hormone replacement therapy (HRT) or surgical treatment.

Objective

The objective of the study was to investigate age at menopause, length of reproductive life, and HRT use in relation to volumetric and areal bone mineral density (vBMD, aBMD), bone size, and strength in women aged 60-64 years.

Design

This was a birth cohort study that followed up for 64 years with prospective measures of age at menarche and menopause and monthly HRT histories.

Setting

The study was conducted in England, Scotland, and Wales.

Participants

Participants includ

SUBMITTER: Kuh D 

PROVIDER: S-EPMC5052353 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature