Urinary Metabotyping of Hepatocellular Carcinoma in a UK Cohort Using Proton Nuclear Magnetic Resonance Spectroscopy.

ABSTRACT:

Background

Discriminatory metabolic profiles have been described in urinary ¹H nuclear magnetic resonance (NMR) spectroscopy studies of African patients with hepatocellular carcinoma (HCC). This study aimed to assess similarities in a UK cohort, where there is a greater etiological diversity.

Methods

Urine from cirrhosis and HCC patients was analyzed using a 600 MHz ¹H NMR system. Multivariate analysis and median group MR spectra comparison identified metabolite alterations between groups. Metabolite identification was achieved through literature reference and statistical total correlation spectroscopy. Diagnostic accuracy was compared to serum alpha-fetoprotein (AFP).

Results

Of the 52 patients recruited, 13 samples from HCC and 25 from cirrhosi

SUBMITTER: Shariff MI 

PROVIDER: S-EPMC5052404 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature