A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration.

ABSTRACT: It is now evident that the cell nucleus undergoes dramatic shape changes during important cellular processes such as cell transmigration through extracellular matrix and endothelium. Recent experimental data suggest that during cell transmigration the deformability of the nucleus could be a limiting factor, and the morphological and structural alterations that the nucleus encounters can perturb genomic organization that in turn influences cellular behavior. Despite its importance, a biophysical model that connects the experimentally observed nuclear morphological changes to the underlying biophysical factors during transmigration through small constrictions is still lacking. Here, we developed a universal chemomechanical model that describes nuclear strains and shapes and predicts threshol

SUBMITTER: Cao X 

PROVIDER: S-EPMC5052451 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature