Direct Tracking of Particles and Quantification of Margination in Blood Flow.

ABSTRACT: Margination refers to the migration of particles toward blood vessel walls during blood flow. Understanding the mechanisms that lead to margination will aid in tailoring the attributes of drug-carrying particles for effective drug delivery. Most previous studies evaluated the margination propensity of these particles via an adhesion mechanism, i.e., by measuring the number of particles that adhered to the channel wall. Although particle adhesion and margination are related, adhesion also depends on other factors. In this study, we quantified the margination propensity of particles of varying diameters (0.53, 0.84, and 2.11 μm) and apparent wall shear rates (30, 61, and 121 s^-1) by directly tracking fluorescent particles flowing through a microfluidic channel. The margination par

SUBMITTER: Carboni EJ 

PROVIDER: S-EPMC5052466 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature