A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP1₁₉.

ABSTRACT: The most widespread Plasmodium species, Plasmodium vivax, poses a significant public health threat. An effective vaccine is needed to reduce global malaria burden. Of the erythrocytic stage vaccine candidates, the 19 kDa fragment of the P. vivax Merozoite Surface Protein 1 (PvMSP1₁₉) is one of the most promising. Our group has previously defined several promiscuous T helper epitopes within the PvMSP1 protein, with features that allow them to bind multiple MHC class II alleles. We describe here a P. vivax recombinant modular chimera based on MSP1 (PvRMC-MSP1) that includes defined T cell epitopes genetically fused to PvMSP1₁₉. This vaccine candidate preserved structural elements of the native PvMSP1₁₉ and elicited cytophilic antibody responses, and CD4+ and

SUBMITTER: Fonseca JA 

PROVIDER: S-EPMC5052570 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature