Increasing The Genetic Admixture of Available Lines of Human Pluripotent Stem Cells.

ABSTRACT: Human pluripotent stem cells (hPSCs) may significantly improve drug development pipeline, serving as an in vitro system for the identification of novel leads, and for testing drug toxicity. Furthermore, these cells may be used to address the issue of differential drug response, a phenomenon greatly influenced by genetic factors. This application depends on the availability of hPSC lines from populations with diverse ancestries. So far, it has been reported that most lines of hPSCs derived worldwide are of European or East Asian ancestries. We have established 23 lines of hPSCs from Brazilian individuals, and we report the analysis of their genomic ancestry. We show that embryo-derived PSCs are mostly of European descent, while induced PSCs derived from participants of a national-wide Brazi

SUBMITTER: Tofoli FA 

PROVIDER: S-EPMC5052616 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature