MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis.

ABSTRACT: MicroRNA-155 (miR-155) is an important regulator of B cells in mice. B cells have a critical role in the pathogenesis of rheumatoid arthritis (RA). Here we show that miR-155 is highly expressed in peripheral blood B cells from RA patients compared with healthy individuals, particularly in the IgD^-CD27^- memory B-cell population in ACPA⁺ RA. MiR-155 is highly expressed in RA B cells from patients with synovial tissue containing ectopic germinal centres compared with diffuse synovial tissue. MiR-155 expression is associated reciprocally with lower expression of PU.1 at B-cell level in the synovial compartment. Stimulation of healthy donor B cells with CD40L, anti-IgM, IL-21, CpG, IFN-α, IL-6 or BAFF induces miR-155 and decreases PU.1 expression. Finally, inhib

SUBMITTER: Alivernini S 

PROVIDER: S-EPMC5052655 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature