Reaction-diffusion basis of retroviral infectivity.

ABSTRACT: Retrovirus particle (virion) infectivity requires diffusion and clustering of multiple transmembrane envelope proteins (Env₃) on the virion exterior, yet is triggered by protease-dependent degradation of a partially occluding, membrane-bound Gag polyprotein lattice on the virion interior. The physical mechanism underlying such coupling is unclear and only indirectly accessible via experiment. Modelling stands to provide insight but the required spatio-temporal range far exceeds current accessibility by all-atom or even coarse-grained molecular dynamics simulations. Nor do such approaches account for chemical reactions, while conversely, reaction kinetics approaches handle neither diffusion nor clustering. Here, a recently developed multiscale approach is considered that applies

SUBMITTER: Sadiq SK 

PROVIDER: S-EPMC5052732 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature