Arginine deiminase pathway enzymes: evolutionary history in metamonads and other eukaryotes.

ABSTRACT:

Background

Multiple prokaryotic lineages use the arginine deiminase (ADI) pathway for anaerobic energy production by arginine degradation. The distribution of this pathway among eukaryotes has been thought to be very limited, with only two specialized groups living in low oxygen environments (Parabasalia and Diplomonadida) known to possess the complete set of all three enzymes. We have performed an extensive survey of available sequence data in order to map the distribution of these enzymes among eukaryotes and to reconstruct their phylogenies.

Results

We have found genes for the complete pathway in almost all examined representatives of Metamonada, the anaerobic protist group that includes parabasalids and diplomonads. Phylogenetic analyses indicate the presence of the comp

SUBMITTER: Novak L 

PROVIDER: S-EPMC5052871 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature