The Relationship of Novel Plasma Proteins in the Early Neonatal Period With Retinopathy of Prematurity.

ABSTRACT:

Purpose

Retinopathy of prematurity (ROP) is a vision-threatening disease associated with abnormal retinal vascular development. Proteins from the insulin-like growth factor pathway are related to ROP. However, there is a paucity of research on the role of other proteins in ROP. The aim of this study was to identify plasma proteins related to clinically significant ROP.

Methods

We measured 1121 plasma proteins in the early neonatal period in infants at risk for ROP using an aptamer-based proteomic technology. The primary aim of the study was to compare plasma protein concentrations in infants who did (n = 12) and did not (n = 23) subsequently develop clinically significant ROP using logistic regression. As a secondary aim, we examined patterns in the proteins across categorie

SUBMITTER: Lynch AM 

PROVIDER: S-EPMC5053115 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature