Randomised clinical trial: the effects of a multispecies probiotic vs. placebo on innate immune function, bacterial translocation and gut permeability in patients with cirrhosis.

ABSTRACT:

Background

Probiotics may correct intestinal dysbiosis and proinflammatory conditions in patients with liver cirrhosis.

Aim

To test the effects of a multispecies probiotic on innate immune function, bacterial translocation and gut permeability.

Methods

In a randomised, double blind, placebo-controlled study, stable cirrhotic out-patients either received a daily dose of a probiotic powder containing eight different bacterial strains (Ecologic Barrier, Winclove, Amsterdam, The Netherlands) (n = 44) or a placebo (n = 36) for 6 months and were followed up for another 6 months.

Results

We found a significant but subclinical increase in neutrophil resting burst (2.6-3.2%, P = 0.0134) and neopterin levels (7.7-8.4 nmol/L, P = 0.001) with probiotics but not with placeb

SUBMITTER: Horvath A 

PROVIDER: S-EPMC5053220 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature