Expression of Programmed Death Receptor Ligand 1 with High Tumor-Infiltrating Lymphocytes Is Associated with Better Prognosis in Breast Cancer.

ABSTRACT:

Purpose

The interaction of programmed death receptor 1 (PD-1) and its ligand, programmed death receptor ligand 1 (PD-L1), negatively regulates immune responses. This study aimed to clarify PD-L1 expression levels in breast cancer through immunohistochemistry (IHC) and to evaluate associations between these findings and clinicopathologic variables, including prognosis.

Methods

PD-L1 expression was analyzed using IHC on tissue microarrays of 465 invasive breast carcinomas.

Results

High PD-L1 expression was demonstrated in 63 of 465 tumors (13.5%). High PD-L1 expression was significantly associated with high histologic grade (p<0.001), negative lymph nodes (p=0.011), early pathologic stage (p=0.025), high tumor-infiltrating lymphocyte (TIL) (p

SUBMITTER: Bae SB 

PROVIDER: S-EPMC5053308 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature