Histomorphological Factors Predicting the Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer.

ABSTRACT:

Purpose

There is no standard targeted therapy for the treatment of triple-negative breast cancer (TNBC). Therefore, its management heavily depends on adjuvant chemotherapy. Using core needle biopsy, this study evaluated the histological factors of TNBC predicting the response to chemotherapy.

Methods

One hundred forty-three TNBC patients who received single-regimen neoadjuvant chemotherapy (NAC) with the combination of doxorubicin, cyclophosphamide, and docetaxel were enrolled. The core needle biopsy specimens acquired before NAC were used to analyze the clinicopathologic variables and overall performance of the predictive model for therapeutic response.

Results

Independent predictors of pathologic complete response after NAC were found to be higher number of tumor in

SUBMITTER: Jung YY 

PROVIDER: S-EPMC5053310 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature