Identification of gene-drug interactions that impact patient survival in TCGA.

ABSTRACT:

Background

With the advent of large scale biological data collection for various diseases, data analysis pipelines and workflows need to be established to build frameworks for integrative analysis. Here the authors present a pipeline for identifying disease specific gene-drug interactions using CNV (Copy Number Variation) and clinical data from the TCGA (The Cancer Genome Atlas) project. Two cancer types were selected for analysis, LGG (Brain lower grade glioma) and GBM (Glioblastoma multiforme), due to the possible progression from LGG to GBM in some cases. The copy number and clinical data were then used to preform survival analysis on a gene by gene basis on sub-populations of patients exposed to a given drug.

Results

Several gene-drug interactions are identified, where t

SUBMITTER: Spainhour JC 

PROVIDER: S-EPMC5053348 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature