Common variation at 10p12.31 near MLLT10 influences meningioma risk.

ABSTRACT: To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)). This finding advances our understanding of the genetic basis of meningioma development.

SUBMITTER: Dobbins SE 

PROVIDER: S-EPMC5053355 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature