Spatial Effects on the Multiplicity of Plasmodium falciparum Infections.

ABSTRACT: As malaria is being pushed back on many frontiers and global case numbers are declining, accurate measurement and prediction of transmission becomes increasingly difficult. Low transmission settings are characterised by high levels of spatial heterogeneity, which stands in stark contrast to the widely used assumption of spatially homogeneous transmission used in mathematical transmission models for malaria. In the present study an individual-based mathematical malaria transmission model that incorporates multiple parasite clones, variable human exposure and duration of infection, limited mosquito flight distance and most importantly geographically heterogeneous human and mosquito population densities was used to illustrate the differences between homogeneous and heterogeneous transmission

SUBMITTER: Karl S 

PROVIDER: S-EPMC5053403 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature