Mitochondrial Haplogroup Influences Motor Function in Long-Term HIV-1-Infected Individuals.

ABSTRACT: Evolutionary divergence of the mitochondrial genome has given rise to distinct haplogroups. These haplogroups have arisen in specific geographical locations and are responsible for subtle functional changes in the mitochondria that may provide an evolutionary advantage in a given environment. Based on these functional differences, haplogroups could define disease susceptibility in chronic settings. In this study, we undertook a detailed neuropsychological analysis of a cohort of long-term HIV-1-infected individuals in conjunction with sequencing of their mitochondrial genomes. Stepwise regression analysis showed that the best model for predicting both working memory and declarative memory were age and years since diagnosis. In contrast, years since diagnosis and sub-haplogroup were signifi

SUBMITTER: Azar A 

PROVIDER: S-EPMC5053473 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature