Spatiotemporal Dynamics of Dexmedetomidine-Induced Electroencephalogram Oscillations.

ABSTRACT: An improved understanding of the neural correlates of altered arousal states is fundamental for precise brain state targeting in clinical settings. More specifically, electroencephalogram recordings are now increasingly being used to relate drug-specific oscillatory dynamics to clinically desired altered arousal states. Dexmedetomidine is an anesthetic adjunct typically administered in operating rooms and intensive care units to produce and maintain a sedative brain state. However, a high-density electroencephalogram characterization of the neural correlates of the dexmedetomidine-induced altered arousal state has not been previously accomplished. Therefore, we administered dexmedetomidine (1mcg/kg bolus over 10 minutes, followed by 0.7mcg/kg/hr over 50 minutes) and recorded high-density e

SUBMITTER: Akeju O 

PROVIDER: S-EPMC5053525 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature