Longitudinal Changes in Protein Carbamylation and Mortality Risk after Initiation of Hemodialysis.

ABSTRACT:

Background and objectives

Carbamylation describes a post-translational protein modification associated with adverse outcomes in ESRD, but the risk implications of changes in carbamylation over time are not well understood.

Design, setting, participants, & measurements

We investigated the 1-year natural history of protein carbamylation in patients initiating maintenance hemodialysis and determined the prognostic value of longitudinal carbamylation changes in relation to mortality. In a nested patient-control study, we measured serial carbamylated albumin concentrations in select participants from a large incident dialysis cohort followed from 2004 to 2005 (n=10,044); 122 individuals who survived at least 90 days but died within 1 year of initiating hemodialysis (patien

SUBMITTER: Kalim S 

PROVIDER: S-EPMC5053789 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature